Blom van Staden, Analike published the artcileThe effect of Aspalathus linearis (Burm.f.) R.Dahlgren and its compounds on tyrosinase and melanogenesis, Computed Properties of 121-79-9, the publication is Scientific Reports (2021), 11(1), 7020, database is CAplus and MEDLINE.
Pigmentation, a process controlled by melanogenesis, plays a vital role in protecting the skin against harmful UV rays. The level of protection is compromised in case of hypopigmentation. This study aimed to evaluate an Aspalathus linearis extract, fractions and phytoconstituents, for their efficacy on melanogenesis stimulation. Fifteen compounds were kinetically assessed against tyrosinase; the rate-limiting enzyme of melanogenesis. Aspalathin and catechin significantly (p value < 0.001) increased the enzymic rate, showing 50% stimulatory effects at 119.70 ± 2.06μg/mL and 143.30 ± 2.74μg/mL, resp., by acting as subversive substrates. Five compounds inhibited the enzyme’s activity, of which four exhibited competitive inhibition. To investigate the mol. interactions between the compounds and the active site, mol. docking was done, using tyrosinase (PBD: 2Y9X) and tyrosinase related protein 1 (PBD: 5M8P). All the compounds docked successfully with acceptable docking scores. Further quant. structure-activity relationship anal. identified potential functional groups, linked to the specific activity. The crude extract, its fractions, and compounds exhibited low antiproliferative activity with 50% cell viability at concentrations higher than 100μg/mL. Finally, both aspalathin and catechin exhibited a significant increase (4.5%) in melanin production at 119.82μg/mL and 76.92μg/mL, resp. This is the first report of A. linearis’ compounds on skin re-pigmentation.
Scientific Reports published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Computed Properties of 121-79-9.
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