Padwa, Albert published the artcileA Rh(II)-catalyzed cycloaddition approach toward the synthesis of komaroviquinone, Safety of Ethyl 2,2-dimethylpent-4-enoate, the main research area is komaroviquinone icetexane core synthesis cyclization cycloaddition rhodium catalyzed.
Using a rhodium(II)-catalyzed cyclization/cycloaddition sequence as the key reaction step, the icetexane core of komaroviquinone (I) was constructed by an intramol. dipolar-cycloaddition of a carbonyl ylide dipole across a tethered π-bond. The ylide was arrived at by cyclization of a rhodium carbenoid intermediate onto a proximal ester group. Efforts toward the preparation of the required precursor for elaboration to the natural product are discussed.
Tetrahedron published new progress about Cyclization. 86549-27-1 belongs to class esters-buliding-blocks, name is Ethyl 2,2-dimethylpent-4-enoate, and the molecular formula is C9H16O2, Safety of Ethyl 2,2-dimethylpent-4-enoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics