Balafouti, Anastasia published the artcileP( OEGMA-co-LMA ) hyperbranched amphiphilic copolymers as self-assembled nanocarriers, Category: esters-buliding-blocks, the main research area is hyperbranched amphiphilic copolymer preparation curcumin drug delivery bioimaging.
We report on the synthesis of novel amphiphilic hyperbranched copolymers, namely Hyperbranched-[poly (ethylene glycol) Me ether methacrylate-co-lauryl methacrylate] (H-[P(OEGMA-co-LMA)]), obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization utilizing the divinyl monomer, ethylene glycol dimethacrylate (EGDMA) as the branching agent. Mol. characterization by size exclusion chromatog. (SEC) and proton NMR (1H-NMR) spectroscopy indicated the success of the polymerization The self-assembly behavior in aqueous media was investigated by light scattering techniques and fluorescence spectroscopy. The hyperbranched copolymers form multimol. aggregates of nanoscale dimensions with a low critical aggregation concentration In addition, the model hydrophobic drug, curcumin (CUR), known also for its intrinsic fluorescence properties, was used in order to investigate the H-[P(OEGMA-co-LMA)] copolymers drug encapsulation ability. Curcumin is successfully loaded into the polymeric nanoparticles, as confirmed by dynamic light scattering and UV-Vis spectroscopy. Interestingly, curcumin hydrophobic interactions with the hyperbranched copolymers result in more well-defined co-assembled nanostructures, in terms of size and size distribution. The mixed copolymer-CUR nano-assemblies consist of small size nanoparticles (<100 nm) which exhibit relatively high size uniformity, colloidal stability and fluorescent properties. Overall, results signify that the biocompatible H-[P(OEGMA-co-LMA)] nanostructures could potentially serve as nanocarrier systems for drug delivery and bio-imaging applications. Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Aggregates. 142-90-5 belongs to class esters-buliding-blocks, name is Dodecyl 2-methylacrylate, and the molecular formula is C16H30O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics