Abdel-Lateef, Mohamed A. published the artcileA specific turn-on fluorescence probe for determination of nitazoxanide based on feasible oxidation reaction with hypochlorite: Applying cobalt ferrite nanoparticles for pre-concentration and extraction of its metabolite from real urine samples, COA of Formula: C12H9N3O5S, the main research area is Cobalt ferrite NPs; Nitazoxanide; Sodium hypochlorite; Spectrofluorimetry; Tizoxanide; Urine analysis.
Nitazoxanide is an antimicrobial compound that was originally developed as an antiprotozoal drug. Recently nitazoxanide has been identified as broad-spectrum antiviral agent and redirected for the remediation of some respiratory tract viral infections. In this study, the spectrofluorimetric technique has been applied to determine Nitazoxanide (NTX) in tablets or its metabolite, tizoxanide (TZD), in human urine samples. The developed methodol. is based on oxidizing NTX (non-fluorescence) into a highly fluorescent product by sodium hypochlorite. The fluorescence emission intensity was measured at 436.5 nm after fluorescence excitation at 362.5 nm. After optimizing all conditions, the anal. procedures and bio-anal. steps were evaluated and validated using ICH and FDA criteria, resp. The method linearity, LOQ, and LOD values of NTX were 1.0-5.0 μg/mL, 0.434, and 0.143 μg/mL, resp. The other novelty side of the presented work is the application of cobalt ferrite (CoFe2O4) nanoparticles (NPs) as a magnetic solid-phase for the pre-concentration and extraction process. The synthesized magnetic nanoparticles were characterized by scanning electron microscope and zeta sizer techniques. Finally, the utilized magnetic nanoparticles exhibited good recovery results for pre-concentration and extraction of NTX or its metabolite from spiked and real human urine samples, resp.
Journal of Pharmaceutical and Biomedical Analysis published new progress about Cobalt ferrite NPs; Nitazoxanide; Sodium hypochlorite; Spectrofluorimetry; Tizoxanide; Urine analysis. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, COA of Formula: C12H9N3O5S.
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