Sangpairoj, Kant published the artcileHexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress, Category: esters-buliding-blocks, the main research area is hexadecanoic acid Halymenia durvillei death human breast cancer cells; autophagic death human triple neg breast cancer ER stress.
To investigate the effect of the hexane solvent fraction of Halymenia durvillei (HDHE) on triple-neg. breast cancer. The phytochem. profile of HDHE was investigated by GC-MS. The cytotoxicity of HDHE against MDA-MB-231 cells was determined The apoptotic and autophagic effects of HDHE were analyzed. The expression of mol. markers controlling apoptosis, autophagy, DNA damage, and endoplasmic reticulum (ER) stress was determined HDHE contains a mixture of fatty acids, mainly hexadecanoic acid. HDHE at a cytotoxic concentration induced apoptotic death of MDA-MB-231 cells through mitochondrial membrane dysfunction, and induction of apoptosis markers, and increased the expression of proteins related to DNA damage response. HDHE also induced the expression of LC-3, a marker of autophagic cell death at a cytotoxic concentration Moreover, HDHE modulated the expression of ER stress genes. The hexadecanoic acid-enriched extract of Halymenia durvillei promotes apoptosis and autophagy of human triple-neg. breast cancer cells. This extract may be further explored as an anticancer agent for triple-neg. breast cancer.
Asian Pacific Journal of Tropical Biomedicine published new progress about Apoptosis. 41114-00-5 belongs to class esters-buliding-blocks, name is Ethyl pentadecanoate, and the molecular formula is C17H34O2, Category: esters-buliding-blocks.
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