Mizumachi, Hideyuki published the artcileCharacterization of dermal sensitization potential for industrial or agricultural chemicals with EpiSensA, Recommanded Product: Dodecyl 2-methylacrylate, the main research area is industrial agricultural chem dermal sensitization potential; DPRA; EpiSensA; KeratinoSensâ? h-CLAT; in vitro; skin sensitization.
The regulatory community is transitioning to the use of nonanimal methods for dermal sensitization assessments; however, some in vitro assays have limitations in their domain of applicability depending on the properties of chems. being tested. This study explored the utility of epidermal sensitization assay (EpiSensA) to evaluate the sensitization potential of complex and/or â²â²difficult to testâ²â?chems. Assay performance was evaluated by testing a set of 20 test chems. including 10 methacrylate esters, 5 silicone-based compounds, 3 crop protection formulations, and 2 surfactant mixtures; each had prior in vivo data plus some in silico and in vitro data. Using the weight of evidence (WoE) assessments by REACH Lead Registrants, 14 of these chems. were sensitizers and, six were nonsensitizers based on in vivo studies (local lymph node assay [LLNA] and/or guinea pig studies). The EpiSensA correctly predicted 16/20 materials with three test materials as false pos. and one silane as false neg. This silane, classified as weak sensitizer via LLNA, also gave a â²â²false neg.â²â?result in the KeratinoSens assay. Overall, consistent with prior evaluations, the EpiSensA demonstrated an accuracy level of 80% relative to available in vivo WoE assessments. In addition, potency classification based on the concentration showing pos. marker gene expression of EpiSensA was performed. The EpiSensA correctly predicted the potency for all seven sensitizing methacrylates classified as weak potency via LLNA (EC3 â?10%). In summary, EpiSensA could identify dermal sensitization potential of these test substances and mixtures, and continues to show promise as an in vitro alternative method for dermal sensitization.
Journal of Applied Toxicology published new progress about Agrochemicals. 142-90-5 belongs to class esters-buliding-blocks, name is Dodecyl 2-methylacrylate, and the molecular formula is C16H30O2, Recommanded Product: Dodecyl 2-methylacrylate.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics