Mancuso, Raffaella published the artcileSynthesis, computational evaluation and pharmacological assessment of acetylsalicylic esters as anti-inflammatory agents, Safety of Hexyl 2-hydroxybenzoate, the main research area is aspirin acetylsalicylic ester antiinflammatory toxicity.
A convenient approach to the synthesis of alkyl esters of aspirin (ASA-OR) has been developed. The synthesis of ASA-OR has been realized in two steps: (1) direct esterification of salicylic acid with alcs. in the presence of dicyclohexylcarbodiimide to give alkyl salicylates (SAL-OR); (2) acetylation of SAL-OR with acetyl chloride to yield ASA-OR. Mol. mechanics simulations, performed to calculate the kinetic radii of several ASA-OR, indicated that the pentyl and hexyl acetylsalicylates possess the best properties to cross cell membranes. The in vitro biol. tests demonstrate their anti-inflammatory activity, superimposable to that of aspirin. The results of our study suggest that ASA-OR may be used as anti-inflammatory drugs for topical application.
Medicinal Chemistry Research published new progress about Cell membrane. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Safety of Hexyl 2-hydroxybenzoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics