Lewin, Anita H. published the artcileCaged Naloxone: Synthesis, Characterization, and Stability of 3-O-(4,5-Dimethoxy-2-nitrophenyl)carboxymethyl Naloxone (CNV-NLX), Recommanded Product: Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, the main research area is caged naloxone dimethoxynitrophenylcarboxymethyl stability photolability diastereomer; 3-O-(α-carboxy-6-nitroveratryl)naloxone; diastereomers; photolabile.
The photolabile analog of the broad-spectrum opioid antagonist naloxone, 3-O-(4,5-dimethoxy-2-nitrophenyl)carboxymethyl naloxone (also referred to as “”caged naloxone””, 3-O-(α-carboxy-6-nitroveratryl)naloxone, CNV-NLX), has been found to be a valuable biochem. probe. While the synthesis of CNV-NLX is simple, its characterization is complicated by the fact that it is produced as a mixture of αR,5R,9R,13S,14S and αS,5R,9R,13S,14S diastereomers. Using long-range and heteronuclear NMR correlations, the 1H NMR and 13C NMR resonances of both diastereomers have been fully assigned, confirming the structures. Monitoring of solutions of CNV-NLX in saline buffer, in methanol, and in DMSO has shown CNV-NLX to be stable for over a week under fluorescent laboratory lights at room temperature Exposure of such solutions to λ 365 nm from a hand-held UV lamp led to the formation of naloxone and CNV-related breakdown products.
ACS Chemical Neuroscience published new progress about Diastereomers. 2982-53-8 belongs to class esters-buliding-blocks, name is Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, and the molecular formula is C11H13NO6, Recommanded Product: Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics