Kramer, Stefan published the artcileHPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation, COA of Formula: C16H30O2, the main research area is antibody immunoconjugate HPMA nanoparticle.
Fast and bioorthogonally reacting nanoparticles are attractive tools for biomedical applications such as tumor pretargeting. In this study, we designed an amphiphilic block copolymer system based on HPMA using different strategies to introduce the highly reactive click units 1,2,4,5-tetrazines (Tz) either at the chain end (Tz-CTA) or statistical into the hydrophobic block. This reactive group undergoes a rapid, bioorthogonal inverse electron-demand Diels-Alder reaction (iEDDA) with trans-cyclooctenes (TCO). Subsequently, this polymer platform was used for the preparation of different Tz-covered nanoparticles, such as micelles and colloids. Thereby it was found that the reactivity of the polymeric micelles is comparable to that of the low molar mass tetrazines. The core-cross-linked micelles can be successfully conjugated at rather low concentrations to large biomacromols. like antibodies, not only in physiol. buffer, but also in human blood plasma, which was confirmed by fluorescence correlation spectroscopy.
Biomacromolecules published new progress about Crosslinking. 142-90-5 belongs to class esters-buliding-blocks, name is Dodecyl 2-methylacrylate, and the molecular formula is C16H30O2, COA of Formula: C16H30O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics