Aplander, Karolina published the artcileMolecular Wipes: Application to Epidemic Keratoconjuctivitis, COA of Formula: C28H37NO9, the main research area is topical skin wipe keratoconjunctivitis pentacosadiynoic acid polyethylene glycol.
Epidemic keratoconjunctivitis (EKC) is a severe disease of the eye, caused by members of the Adenoviridae (Ad) family, with symptoms such as keratitis, conjunctivitis, pain, edema, and reduced vision that may last for months or years. There are no vaccines or antiviral drugs available to prevent or treat EKC. It was found previously that EKC-causing Ads use sialic acid as a cellular receptor and demonstrated that soluble, sialic acid-containing mols. can prevent infection. In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC50 = 0.9 μM) and Ad infectivity (IC50 = 0.7 μM). The mechanism of action is to aggregate virus particles and thereby prevent them from binding to ocular cells. Such formulations may be used for topical treatment of adenovirus-caused EKC.
Journal of Medicinal Chemistry published new progress about Adenoviridae. 882847-32-7 belongs to class esters-buliding-blocks, name is 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid, and the molecular formula is C28H37NO9, COA of Formula: C28H37NO9.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics