Sakai, Takeo published the artcileTotal Synthesis of Brevisamide Using an Oxiranyl Anion Strategy, Application In Synthesis of 120157-98-4, the main research area is brevisamide total synthesis coupling etherification hydrogenation; diastereoselective synthesis brevisamide; nucleophilic substitution total synthesis brevisamide; Horner Wadsworth Emmons total synthesis brevisamide.
A total synthesis of brevisamide, a marine monocyclic ether amide isolated from the dinoflagellate Karenia brevis, has been achieved in 18 steps starting from 4-(benzyloxy)butanol. The synthesis involves oxiranyl anion coupling between an epoxy sulfone and a triflate, intramol. etherification of a hydroxy-bromoketone, diastereoselective introduction of the axial Me group by hydroxyl-directed hydrogenation of an exocyclic olefin, and installation of an acetamide side chain by nucleophilic substitution of an N-acetyl carbamate. The dienal side chain is assembled using a Horner-Wadsworth-Emmons reaction to complete the synthesis.
Journal of Organic Chemistry published new progress about Coupling reaction. 120157-98-4 belongs to class esters-buliding-blocks, name is tert-Butyl acetylcarbamate, and the molecular formula is C7H13NO3, Application In Synthesis of 120157-98-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics