Jeon, Woo-Young published the artcileMicrobial production of sebacic acid from a renewable source: production, purification, and polymerization, SDS of cas: 110-42-9, the main research area is sebacate production plant oil engineering omega oxidation Candida; nylon 610 synthesis sebacate production C10 FAME biotransformation Candida.
Sebacic acid (SA) is an aliphatic ten-carbon dicarboxylic acid (1,10-decanedioic acid) with a variety of industrial applications, including the production of plasticizers, lubricants, cosmetics, and plastics. Currently, SA is produced exclusively from alk. pyrolysis of castor oil. Herein, we present an environmentally friendly green route of SA production from plant oil-derived sources by microbial ω-oxidation We genetically engineered β-oxidation-blocked diploid yeast Candida tropicalis, and created an effective microbial cell factory with an increase of 46% in SA production by overexpression of genes involved in ω-oxidation of hydrocarbons compared to the original strain. A biotransformation process of SA production from decanoic acid Me ester was developed to overcome the challenges of high-d. cell culture, substrate feed, substrate/intermediate toxicity, and foam generation. Fed-batch production of engineered C. tropicalis resulted in a molar yield of above 98%, a productivity of 0.57 g L-1 h-1, and a final titer of 98.3 g L-1 in a 5-L fermenter and the results were successfully reproduced using a larger scale 50-L fermenter. The produced SAs were successfully purified to >99.8% using acid precipitation and recrystallization Finally, bio-nylon 610 was successfully synthesized by polymerization of the purified SA with hexamethylenediamine and showed thermal properties very similar to those of com. available nylon 610. The processes developed and described in this study can be employed to produce and isolate SA for the synthesis of bio-nylons, using environmentally friendly procedures based on microbial biotransformation with potential industrial applications.
Green Chemistry published new progress about Candida tropicalis. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, SDS of cas: 110-42-9.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics