Ohlmann, Dominik M. published the artcileRegioselective Synthesis of β-Aryl- and β-Amino-Substituted Aliphatic Esters by Rhodium-Catalyzed Tandem Double-Bond Migration/Conjugate Addition, Recommanded Product: Ethyl 5-methylhex-5-enoate, the main research area is unsaturated ester rhodium phosphite catalyst isomerization conjugate addition; arylborate amine nucleophile conjugate addition unsaturated ester; ester aryl amino substituted derivative preparation.
Rhodium-phosphite catalysts were found to effectively mediate double-bond migrations within unsaturated esters. Once the double-bond is in conjugation with the carboxylate group, they also catalyze the Michael addition of carbon and nitrogen nucleophiles. In the presence of these catalysts, unsaturated carboxylates enter a dynamic equilibrium of positional and geometrical double-bond isomers. The conjugated species are continuously removed through 1,4-additions with formation of β-amino esters or β-arylated products, depending on the nucleophile employed. The applicability of both protocols to a range of substrates, such as fatty esters of different chain lengths and double-bond positions, and several nucleophiles including arylborates and primary and secondary amines, is demonstrated.
Chemistry – A European Journal published new progress about Aliphatic esters Role: SPN (Synthetic Preparation), PREP (Preparation) (β-aryl). 39495-82-4 belongs to class esters-buliding-blocks, name is Ethyl 5-methylhex-5-enoate, and the molecular formula is C9H16O2, Recommanded Product: Ethyl 5-methylhex-5-enoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics