Singh, Om V. published the artcileIridium(I)-catalyzed regio- and enantioselective allylic amidation, Application In Synthesis of 120157-98-4, the main research area is iridium catalyst phosphoramidite ligand enantioselective regioselective allylic amidation carbonate; allylic amine protected asym preparation; amino acid preparation allylic amine oxidation; cytoxzone preparation methoxyphenylallylamine reactant.
Iridium(I)-catalyzed intermol. allylic amidation of Et allyl carbonates with soft nitrogen nucleophiles under completely ‘salt-free’ conditions is described. A combination of [Ir(COD)Cl]2 catalyst, chiral phosphoramidite I as a ligand, and DBU as a base in THF effects the reaction. For example, the allylic amidation of EtOCO2CH2CH:CHR (R = n-Pr, Ph) with NR1R2 (R1 = Ac, R2 = Boc; R1 = R2 = Boc; R1 = Cbz, R2 = Boc; R1 = R2 = Cbz) with catalyst [Ir(COD)Cl]2 and ligand I in presence of DBU in THF proceeded with excellent regio- and enantioselectivities to afford the branched N-protected allylic amines II. II (R = Ph) was converted to α-amino acid III in one step and to β-amino acid IV in two steps. Similarly, II (R = C6H4OMe-4) was conveniently used in the asym. synthesis of (-)-cytoxazone.
Tetrahedron Letters published new progress about Amidation (allylic). 120157-98-4 belongs to class esters-buliding-blocks, name is tert-Butyl acetylcarbamate, and the molecular formula is C7H13NO3, Application In Synthesis of 120157-98-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics