Mascini, Marcello published the artcileHairpin DNA-AuNPs as molecular binding elements for the detection of volatile organic compounds, Related Products of esters-buliding-blocks, the main research area is volatile organic compound hairpin DNA gold nanoparticle; AuNPs; E-nose; Gas-sensors; Hairpin DNA; In-silico screening; Multivariate analysis; QCMs; VOCs.
Hairpin DNA (hpDNA) loops were used for the first time as mol. binding elements in gas anal. The hpDNA loops sequences of unpaired bases were studied in-silico to evaluate the binding vs. four chem. classes (alcs., aldehydes, esters and ketones) of volatile organic compounds (VOCs). The virtual binding score trend was correlated to the oligonucleotide size and increased of about 25% from tetramer to hexamer. Two tetramer and pentamer and three hexamer loops were selected to test the recognition ability of the DNA motif. The selection was carried out trying to maximize differences among chem. classes in order to evaluate the ability of the sensors to work as an array. HpDNA-AuNPs were deposited onto 20 MHz quartz crystal microbalances (QCMs) to form the gas piezoelec. sensors. An estimation of relative binding affinities was obtained using different amounts of eight VOCs (ethanol, 3-methylbutan-1-ol, 1-pentanol, octanal, nonanal, Et acetate, Et octanoate, and butane-2,3-dione) representative of the four chem. classes. In agreement with the predicted simulation, hexamer DNA loops improved by two orders of magnitude the binding affinity highlighting the key role of the hpDNA loop size. Using the sensors as an array a clear discrimination of VOCs on the basis of mol. weight and functional groups was achieved, analyzing the exptl. with principal components anal. (PCA) demonstrating that HpDNA is a promising mol. binding element for anal. of VOCs.
Biosensors & Bioelectronics published new progress about Aldehydes Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 106-32-1 belongs to class esters-buliding-blocks, name is Ethyl octanoate, and the molecular formula is C10H20O2, Related Products of esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics