Martinez-Mingo, Mario published the artcileOvercoming the Necessity of γ-Substitution in δ-C(sp3)-H Arylation: Pd-Catalyzed Derivatization of α-Amino Acids, Application In Synthesis of 10047-10-6, the main research area is palladium catalyzed arylation alpha amino acid amine derivative; arylation amino acid heteroaryl aryl iodide; pyridyl sulfonyl directing group density functional theory.
Despite the emergence of catalytic C(sp3)-H arylation at the remote δ-position via challenging six-membered ring cyclometalation, the requirement of blocking the more reactive γ-position represents a restricting limitation. The use of the removable N-(2-pyridyl)sulfonyl directing group provides a viable solution to this challenge, expanding the scope of the Pd-catalyzed δ-C-H arylation of α-amino acid and amine derivatives with (hetero)aryl iodides. This method is compatible with complex, multifunctional structures at either reaction partner. Exptl. and d. functional theory studies provide insights about the underlying factors controlling site selectivity.
ACS Catalysis published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 10047-10-6 belongs to class esters-buliding-blocks, name is Methyl 2-aminopentanoate hydrochloride, and the molecular formula is C6H14ClNO2, Application In Synthesis of 10047-10-6.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics