Hargest, Virginia published the artcileAstrovirus replication is inhibited by nitazoxanide in vitro and in vivo, Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, the main research area is nitazoxanide antiviral agent astrovirus replication; antiviral agents; astrovirus; diarrhea; viral replication.
Astroviruses (AstV) are a leading cause of diarrhea, especially in the very young, the elderly, and immunocompromised populations. Despite their significant impact on public health, no drug therapies for astrovirus have been identified. In this study, we fill this gap in knowledge and demonstrate that the FDA-approved broad-spectrum anti-infective drug nitazoxanide (NTZ) blocks astrovirus replication in vitro with a 50% effective concentration (EC50) of approx. 1.47 μM. It can be administered up to 8 h postinfection and is effective against multiple human astrovirus serotypes, including clin. isolates. Most importantly, NTZ reduces viral shedding in vivo, exhibiting its potential as a future clin. therapeutic.
Journal of Virology published new progress about Antiviral agents Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.
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Ester – an overview | ScienceDirect Topics