Chen, Chen published the artcileOptimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility, Application In Synthesis of 61675-94-3, the main research area is phenylpyrazolopyrimidine preparation corticotropin releasing factor 1 antagonist lipophilicity solubility.
In an effort to identify potent CRF1 antagonists with proper physicochem. properties, a series of 3-phenylpyrazolo[1,5-a]pyrimidines bearing polar groups, such as amino, hydroxyl, methoxy, sulfoxide, were designed and synthesized. Several positions of the core structure were identified, where a polar group was tolerated with slight reduction in receptor binding. NBI 30545 (I) was found to have good binding affinity and potent antagonistic activity at the human CRF1 receptor. Moreover, this compound had proper lipophilicity (log D = 2.78) and good solubility in water (>10 mg/mL), and exhibited good plasma and brain exposure when given orally.
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 61675-94-3 belongs to class esters-buliding-blocks, name is Ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, and the molecular formula is C9H16O4, Application In Synthesis of 61675-94-3.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics