Shibata, Yoshihiro published the artcileSynthesis and structure-activity relationships of 2-aminoacetamide derivatives as peroxisome proliferator-activated receptor α/γ dual agonists, Application of tert-Butyl acetylcarbamate, the main research area is zwitterionic aminoacetamide preparation peroxisome proliferator activated receptor agonist antidiabetic.
The design, syntheses, and structure-activity relationships of novel zwitterionic compounds 2-aminoacetamides I [R = NH2, azetidinyl, piperidinyl, etc.; R1 = H, Me; R2 = H, Me] and II [R = NHC(O)Me, C(O)NHMe] as nonthiazolidinedione-based peroxisome proliferator-activated receptor (PPAR) α/γ dual agonists was described. Further optimization was also carried out to improve the stability while maintaining the other favorable profile features including potent PPARα/γ dual agonistic activity. The amide derivatives were stable in acidic conditions and decreased plasma glucose and plasma triglyceride levels significantly without marked weight gain.
Chemical & Pharmaceutical Bulletin published new progress about Amines Role: RCT (Reactant), RGT (Reagent), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 120157-98-4 belongs to class esters-buliding-blocks, name is tert-Butyl acetylcarbamate, and the molecular formula is C7H13NO3, Application of tert-Butyl acetylcarbamate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics