Schoneich, Sonia published the artcileDynamic pressure gradient modulation for comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection, Product Details of C9H18O2, the main research area is dynamics pressure modulation comprehensive gas chromatog flight mass spectrometry; Comprehensive two-dimensional gas chromatography; Dynamic pressure gradient modulation; Flow modulation; Mass spectrometry.
Dynamic pressure gradient modulation (DPGM) is studied for comprehensive 2-dimensional gas chromatog. (GC × GC) with time-of-flight mass spectrometry (TOFMS) detection. With DPGM, a com. pneumatic pulse valve is opened to introduce a suitably high auxiliary gas pressure at a T-junction connecting the 1st dimension (1D) and 2nd dimension (2D) columns during the modulation period (PM), temporarily stopping the 1D flow. The valve is then closed for the duration of a pulse width (pw) to re-inject temporally focused 1D eluate onto the 2D column for separation This flow modulation technique is compatible with TOFMS detection using a 2D flow rate of 4 mL/min for the separation of a 90-component test mixture A 25 min separation window using a PM = 1 s and pw = 200 ms for full modulation (and 100% duty cycle) provided an average 1Wb = 4.5 s and 2Wb = 130 ms for a 2-dimensional peak capacity of nc,2D = 2700 (100 peaks per min). The detector response enhancement factor (DREF) serves as a metric for the enhanced sensitivity of the modulated relative to the unmodulated 1D peaks, with DREFs ranging between 10 and 20 and about a 5-fold improvement in signal-to-noise ratio (S/N). The bilinear quality of the GC × GC data is studied using the chemometric method parallel factor anal. (PARAFAC). Since PARAFAC requires sufficiently trilinear data, the reproducibility of the 2D peak shape for a given analyte is confirmed using lack-of-fit (LOF) and percent variation (R2) metrics. The limit-of-detection (LOD) for the representative analyte hexadecane is determined using PARAFAC, providing an LOD of 0.7 ppb (±0.03 ppb) for 3 replicates. Seven heavily overlapped analytes are also fully resolved by PARAFAC down to the part-per-million (ppm) concentration level, producing reproducible spectra with a majority of spectral match values (MV) over 800 (relative standard deviation ≤ 7.1%). This study provides promising results for DPGM as a flow modulation technique compatible with GC × GC-TOFMS, providing high sensitivity data suitable for chemometric anal.
Journal of Chromatography A published new progress about Alkanes Role: ANT (Analyte), PEP (Physical, Engineering or Chemical Process), PRP (Properties), ANST (Analytical Study), PROC (Process). 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, Product Details of C9H18O2.
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