Mu, Yu published the artcileEfficient synthesis of tetrahydrofurans with chiral tertiary allylic alcohols catalyzed by Ni/P-chiral ligand DI-BIDIME, Quality Control of 623-50-7, the main research area is oxoethoxypropyne preparation nickel chiral phosphorus catalyst enantioselective reductive cyclization; hydroxy methylidenetetrahydrofuran preparation.
Efficient nickel-catalyzed stereoselective asym. intramol. reductive cyclization of O-alkynones was reported. A P-chiral bisphosphine ligand DI-BIDIME was found to be effective for constructing versatile functionalized chiral THF rings using triethylsilane as the reducing reagent. Practical synthesis of tetrahydrofurans with chiral tertiary allylic alcs. was achieved in high yields (99%), which have excellent stereoselectivity (>99 : 1 E/Z) and enantioselectivity (>99 : 1 er) with a very broad substrate scope. A total of thirty-seven O-alkynones were synthesized and applied in this reaction successfully. The reaction was scaled up to gram scale without loss of its enantioselectivity. The ligand effects and reaction mechanism were investigated in detail. Meanwhile, the developed method for tetrahydrofurans with chiral tertiary allylic alcs. enabled the efficient synthesis of dehydroxycubebin and chiral dibenzocyclooctadiene skeletons, and was anticipated to find wider applications in organic synthesis and chem. biol.; two new discovered reactions of O-alkynone with DI-BIDIME using different metal precursors would further expand new research fields and attract more interesting explorations in the future.
Catalysis Science & Technology published new progress about Diastereoselective synthesis. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Quality Control of 623-50-7.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics