Hamed, Manal A. published the artcileBioactive compounds and therapeutic role of Brassica oleracea L. seeds in rheumatoid arthritis rats via regulating inflammatory signalling pathways and antagonizing interleukin-1 receptor action, Product Details of C23H46O2, the main research area is Brassica seed antiinflammatory interleukin1R rheumatoid arthritis; Brassica oleracea L.; IL-1 receptor antagonist; arthritis index; oxidative stress; phenolic compounds; rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease characterized by aggressive and systematic polyarthritis. The present study aimed to isolate and identify the phenolic constituents in Brassica oleracea L. (Brassicaceae) seeds methanolic extract and evaluates its effect against rheumatoid arthritis in rats referring to the new therapy; interleukin-1 receptor antagonist (IL-1RA). The GC/MS profiling of the plant was determined Arthritis induction was done using complete Freund′s adjuvant. Arthritis severity was assessed by percentage of edema and arthritis index. IL-1 receptor type I gene expression, interleukin-1β (IL-1β), oxidative stress markers, protein content, inflammatory mediators, prostaglandin-E2 (PGE2), genetic abnormalities and the histopathol. features of ankle joint were evaluated. For the first time twelve phenolic compounds had been isolated from the seeds extract Treatment with extract and IL-1RA improved the tested parameters by variable degrees. RA is an irreversible disease, where its severity increases with the time of induction. Brassica oleracea L. seeds extract is considered as a promising anti-arthritis agent. IL-1 RA may be considered as an unusual therapeutic agent for RA disease. More studies are needed to consider the seeds extract as a nutraceutical agent and to recommend IL-1RA as a new RA drug.
Biomarkers published new progress about Anti-inflammatory agents. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Product Details of C23H46O2.
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