Synthesis of benorylate was written by Shen, Guang-zhi;Zou, Gui-hua;Cai, Yu-ting;Wu, Yi-yan. And the article was included in Liaoning Huagong in 2009.Related Products of 5003-48-5 The following contents are mentioned in the article:
Two synthetic routes of benorylate were put forward and compared in this paper. At last, the second synthetic route which used aspirin and acetaminophen as raw materials and PEG1000 as phase transfer catalyst in esterification was selected to prepare benorylate, and the yield of benorylate can reach 92%. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics