A simple and efficient copper oxide-catalyzed Barbier-Grignard reaction of unactivated aryl or alkyl bromides with ester was written by Gao, Fei;Deng, Xiang-Jun;Tang, Yu;Tang, Jin-Peng;Yang, Jun;Zhang, Yuan-Ming. And the article was included in Tetrahedron Letters in 2014.COA of Formula: C7H14O3 The following contents are mentioned in the article:
Tertiary alc. compounds were synthesized by Barbier-Grignard reaction of unactivated alkyl or aryl bromides with esters in THF at 65° catalyzed by CuO in good to high yields. The reaction is highly chemoselective. The mechanism involving the leaving group of R2O–group is discussed. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9COA of Formula: C7H14O3).
Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C7H14O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics