Lithium bromide-catalyzed solvent-free method for synthesis of 2-substituted benzimidazoles and imidazopyridines was written by Dekhane, Deepak V.;Pawar, Shivaji S.;Gupta, Sunil V.;Shingare, Murlidhar S.;Thore, Shivaji N.. And the article was included in Chinese Chemical Letters in 2010.Related Products of 763-69-9 The following contents are mentioned in the article:
The first successful lithium bromide mediated solvent-free condensation of arylenediamine and esters to obtain 2-substituted benzimidazole and imidazopyridine in good to excellent yields was described. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Related Products of 763-69-9).
Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 763-69-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics