Wipf, Peter published the artcileSynthesis of anti-inflammatory α- and β-linked acetamido pyranosides as inhibitors of toll-like receptor 4 (TLR4), Formula: C14H19NO8, the publication is Tetrahedron Letters (2015), 56(23), 3097-3100, database is CAplus and MEDLINE.
The low-mol.-weight iso-Pr 2-acetamido-α-glucoside I (R = AcO, R1 = H; (C34)) inhibits toll-like receptor 4 (TLR4) in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. The authors used a Cu(II)-mediated solvolysis of anomeric oxazolines and an acid-mediated conversion of β-glucosamine- and β-galactosamine pentaacetates to generate analogs of C34 at the anomeric C and at C(4) of the pyranose ring. These compounds were evaluated for their effect on TLR4-mediated inflammatory signaling in cultured enterocytes and monocytes. Their efficacy was confirmed using a NF-κB-luciferase reporter mouse, thus establishing a structure-activity relationship (SAR) study in this series and identifying the more efficacious iso-Pr 2-acetamido-α-galactoside I (R = H, R1 = AcO).
Tetrahedron Letters published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C4Br2N2O4S, Formula: C14H19NO8.
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https://en.wikipedia.org/wiki/Ester,
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