Vainio, S. K. published the artcileDimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation, Name: Dimethyl fumarate, the publication is EJNMMI Research (2022), 12(1), 6, database is CAplus and MEDLINE.
Abstract: Background: Di-Me fumarate (DMF) is an oral immunomodulatory drug used in the treatment of autoimmune diseases. Here, we sought to study whether the effect of DMF can be detected using positron emission tomog. (PET) targeting the 18-kDa translocator protein (TSPO) in the focal delayed-type hypersensitivity rat model of multiple sclerosis (fDTH-EAE). The rats were treated orally twice daily from lesion activation (day 0) with either vehicle (tap water with 0.08% Methocel, 200μL; control group n = 4 (3 after week four)) or 15 mg/kg DMF (n = 4) in 0.08% aqueous Methocel (200μL) for 8 wk. The animals were imaged by PET using the TSPO tracer [18F]GE-180 in weeks 0, 1, 2, 4, 8, and 18 following lesion activation, and the non-displaceable binding potential (BPND) was calculated Immunohistochem. staining for Iba1, CD4, and CD8 was performed in week 18, and in sep. cohorts of animals, following 2 or 4 wk of treatment. Results: Using the fDTH-EAE model, DMF reduced the [18F]GE-180 BPND in the DMF-treated animals compared to control animals after 1 wk of treatment (two-tailed unpaired t test, p = 0.031), but not in weeks 2, 4, 8, or 18 when imaged in vivo by PET. Immunostaining for Iba1 showed that DMF had no effect on the perilesional volume or the core lesion volume after 2 or 4 wk of treatment, or at 18 wk. However, the optical d. (OD) measurements of CD4+ staining showed reduced OD in the lesions of the treated rats. Conclusions: DMF reduced the microglial activation in the fDTH-EAE model after 1 wk of treatment, as detected by PET imaging of the TSPO ligand [18F]GE-180. However, over an extended time course, reduced microglial activation was not observed using [18F]GE-180 or by immunohistochem. for Iba1+ microglia/macrophages. Addnl., DMF did affect the infiltration of CD4+ and CD8+ T-lymphocytes at the fDTH-EAE lesion.
EJNMMI Research published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C18H16N2O6, Name: Dimethyl fumarate.
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