Pujol, Anais M. published the artcileA sulfur tripod glycoconjugate that releases a high-affinity copper chelator in hepatocytes, Category: esters-buliding-blocks, the publication is Angewandte Chemie, International Edition (2012), 51(30), 7445-7448, S7445/1-S7445/24, database is CAplus and MEDLINE.
Th authors developed glycoconjugates 1 from a tripodal Cu1 chelator L2 derived from nitrilotriacetic acid (NTA) by an extension with three cysteines, which exhibits an affinity for Cu1 as high as that of metallothioneins, and a ligand of the asialoglycoprotein receptor (ASGP-R), and the Cu-chelating property in vitro and efficiency in two hepatic cell lines were tested. The results showed that the glycoconjugate 1 can be considered as a vector delivering L2, the active compound, at the right place to chelate excess Cu1. For the Wilson’s disease patients, 1 could represent an interesting concept of a prodrug to be further developed.
Angewandte Chemie, International Edition published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Category: esters-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics