Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention was written by Krumb, Matthias;Jaeger, Maximilian;Voss, Alice;Immig, Loreen;Peters, Karin;Kowalczyk, Danuta;Bufe, Albrecht;Opatz, Till;Holst, Otto;Vogel, Christian;Peters, Marcus. And the article was included in Chemistry – A European Journal in 2021.Category: esters-buliding-blocks The following contents are mentioned in the article:
Arabinogalactan, a micro-heterogeneous polysaccharide occurring in plants, is known for its allergy-protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a preventive manner, due to the constant rise of atopic diseases worldwide. The structural origin of the allergy-protective activity of arabinogalactan is, however, still unclear and isolation of the polysaccharide is not feasible for pharmaceutical applications due to a variation of the activity of the natural product and contaminations with endotoxins. Therefore, a pentasaccharide partial structure was selected for total synthesis and subsequently coupled to a carrier protein to form a neoglycoconjugate. The allergy-protective activity of arabinogalactan could be reproduced with the partial structure in subsequent in vivo experiments This is the first example of a successful simplification of arabinogalactan with a single partial structure while retaining its allergy-preventive potential. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Category: esters-buliding-blocks).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics