Synthesis and antibacterial profiles of targeted triclosan derivatives was written by Howse, Gemma L.;Bovill, Richard A.;Stephens, Peter J.;Osborn, Helen M. I.. And the article was included in European Journal of Medicinal Chemistry in 2019.Electric Literature of C16H22O11 The following contents are mentioned in the article:
There is an ongoing urgent need for new targeted antibacterial compounds with novel mechanisms of action for the treatment of infections caused by bacteria that are resistant to currently available materials. Herein we report the synthesis and characterization of four α-D-glycopyranosides, e.g. I, and three β-D-glycopyranosides of the broad antibacterial agent triclosan, in generally good synthetic yields, and with excellent purity. Each triclosan glycoside was analyzed to determine its ability to inhibit the growth of a wide range of Gram-neg. and Gram-pos. organisms, including many of clin. significance. All of the triclosan glycosides that were synthesized demonstrated antibacterial activity against many of the organisms that were examined Two Bacillus strains could be identified from various strains of Bacillus and Staphylococcus after inoculation onto nutrient agar Number 2 with 0.25 μg/mL triclosan-α-D-glucopyranoside I. This glucoside may, therefore, be of use for the isolation and identification of the food-poisoning organism Bacillus cereus. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Electric Literature of C16H22O11).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C16H22O11
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics