Gautom, Trishnamoni published the artcileStructural basis of terephthalate recognition by solute binding protein TphC, Name: Potassium 4-nitrophenyl sulfate, the publication is Nature Communications (2021), 12(1), 6244, database is CAplus and MEDLINE.
Biol. degradation of Polyethylene terephthalate (PET) plastic and assimilation of the corresponding monomers ethylene glycol and terephthalate (TPA) into central metabolism offers an attractive route for bio-based mol. recycling and bioremediation applications. A key step is the cellular uptake of the non-permeable TPA into bacterial cells which has been shown to be dependent upon the presence of the key tphC gene. However, little is known from a biochem. and structural perspective about the encoded solute binding protein, TphC. Here, we report the biochem. and structural characterization of TphC in both open and TPA-bound closed conformations. This anal. demonstrates the narrow ligand specificity of TphC towards aromatic para-substituted dicarboxylates, such as TPA and closely related analogs. Further phylogenetic and genomic context anal. of the tph genes reveals homologous operons as a genetic resource for future biotechnol. and metabolic engineering efforts towards circular plastic bio-economy solutions
Nature Communications published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Name: Potassium 4-nitrophenyl sulfate.
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