Dullin, Anja’s team published research in ChemMedChem in 1 | CAS: 106391-88-2

Dullin, Anja published the artcileSynthesis and cytotoxicity of enantiomerically pure [1,2-diamino-1-(4-fluorophenyl)-3-methylbutane]platinum(II) complexes, HPLC of Formula: 106391-88-2, the publication is ChemMedChem (2006), 1(6), 644-653, database is CAplus and MEDLINE.

A series of leaving group derivatives of enantiomerically pure [1,2-diamino-1-(4-fluorophenyl)-3-methylbutane]platinum(II) complexes were synthesized and tested for cytotoxicity. The enantiomeric purity was determined by ¹H NMR spectroscopy on the final diamines after derivation with (1R)-myrtenal. For coordination to platinum, the diamines were reacted with K₂Ptl₄. The treatment of diiodoplatinum(II) complexes (4F-Ph/iProp-Ptl₂) with Ag₂SO₄ resulted in the sulfatoplatinum(II) complexes (4F-Ph/iProp-PtSO₄), which can be easily transformed to dichloroplatinum(II) complexes (4F-Ph/iProp-PtCl₂) with 2 N HCl. The importance of the leaving groups and the configuration at the diamine ligand on the antiproliferative effects was evaluated on the hormone-dependent MCF-7 and the hormone-independent MDA-MB 231 breast cancer cell lines as well as the LNCaP/FGC prostate cancer cell line. (R,R)-4F-Ph/iProp-PtCl₂ was identified as the most active platinum(II) complex. The 3-Me group increased antiproliferative effects relative to the [1,2-diamino-1-(4-fluorophenyl)butane]platinum(II) complexes described in an earlier study.

ChemMedChem published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, HPLC of Formula: 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics