Ding, Yun published the artcileDesign and Synthesis of Biaryl DNA-Encoded Libraries, HPLC of Formula: 363186-06-5, the publication is ACS Combinatorial Science (2016), 18(10), 625-629, database is CAplus and MEDLINE.
DNA-encoded library technol. (ELT) is a powerful tool for the discovery of new small-mol. ligands to various protein targets. Here we report the design and synthesis of biaryl DNA-encoded libraries based on the scaffold of 5-formyl 3-iodobenzoic acid. Three reactions on DNA template, acylation, Suzuki-Miyaura coupling and reductive amination, were applied in the library synthesis. The three cycle library of 3.5 million diversity has delivered potent hits for phosphoinositide 3-kinase α (PI3Kα).
ACS Combinatorial Science published new progress about 363186-06-5. 363186-06-5 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters, name is Benzyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate, and the molecular formula is C20H24BNO4, HPLC of Formula: 363186-06-5.
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