Hypromellose – Collagen hydrogels/sesame oil organogel based bigels as controlled drug delivery systems was written by Corredor-Chaparro, Maira Yohana;Vargas-Riveros, Daniela;Mora-Huertas, Claudia Elizabeth. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Safety of Glyceryl monostearate The following contents are mentioned in the article:
The search for novel strategies to formulate bioactive mols. for topical administration is a matter of permanent interest in the pharmaceutical field. As a contribution, the present work deepens the bigels, i.e., matrix-in-matrix systems resulting from mixing a hydrogel and an organogel. Hypromellose, collagen, gelatin, alginate, sesame oil, medium-chain triglycerides, and iso-Pr myristate were included among the starting materials investigated. Nonetheless, the bigels’ homogeneity and stability are determined by the nature and proportion of the starting materials and operating conditions used during their preparation On the other hand, bigels exhibit a different structure than the starting gels and other related systems such as emulgels, which govern their rheol. and texture behaviors, and modulate the drug delivery, as evidenced through the tests using diclofenac in its dissociated and non-dissociated forms. On this basis, this semisolid system attracts attention to developing versatile pharmaceutical products wherein controlled release of active mols. is intended. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Safety of Glyceryl monostearate).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Glyceryl monostearate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics