Biopolymers published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Formula: C10H19NO3.
Asano, Akiko published the artcileEffects of amino acids and chirality for molecular folding of desoxazoline-ascidiacyclamide derivatives: x-ray crystal structures of four cyclic octapeptides including unusual amino acids, cyclo(-Ile-aThr-D-Val-Thz-)2, cyclo(-Ala-aThr-D-Val-Thz-Ile-aThr-D-Val-Thz-), cyclo(-Val-aThr-D-Val-Thz-Ile-aThr-D-Val-Thz-), and cyclo(-Ile-aThr-Val-Thz-Ile-aThr-D-Val-Thz-), Formula: C10H19NO3, the publication is Biopolymers (2001), 58(3), 295-304, database is CAplus and MEDLINE.
The desoxazoline derivative of ascidiacyclamide, cyclo(-L-Ile-L-allo-threonine-D-Val-thiazole-)2 (1), was modified to disturb the C2-symmetry. Three addnl. derivatives of ascidiacyclamide were prepared as follows: the Ile1 residue of 1 was replaced with Ala (2) or Val (3), and the D-Val3 residue was replaced with Val (4). The crystal structures of 1-4 were analyzed by x-ray diffraction methods. The mols. of all compounds were folded and this type of structure has not been observed so far in x-ray structures of ascidiacyclamide derivatives except for patellamide D. The folding patterns of 1-4 were similar to each other and resembled that of patellamide. The asym. modifications at position 1 caused the conformational changes at local area, and these were related to peptide-peptide and peptide-solvent interactions. Despite the diverse backbone conformation generated by the epimeric modification at position 3, the entire mol. of 4 was folded. These results indicate that (1) the desoxazoline-ascidiacyclamides favored the folded structures, and (2) modifications of the side chain size at position 1 and the chirality at position 3 introduced the local conformational changes to the derivatives, suggesting that (3) the lack of the oxazoline block leads to conformational flexibility in 1-4, which accept the conformational change with no drastic change on the entire structure.
Biopolymers published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Formula: C10H19NO3.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics