Al-Sinjilawi, Hadeel T. published the artcileSynthesis and antibacterial activity of some novel 4-oxopyrido[2,3-a]phenothiazines, SDS of cas: 924-99-2, the publication is Archiv der Pharmazie (Weinheim, Germany) (2014), 347(11), 861-872, database is CAplus and MEDLINE.
A series of substituted 4-oxopyrido[2,3-a]phenothiazine-3-carboxylic acids I [R = H ; X = H, CH3, OCH3, Cl] was prepared via cyclization of 4-oxoquinoline-3-carboxylates II, followed by hydrolysis of the resultant esters I [R = C2H5]. Synthesized carboxylic acids I [R = H] were evaluated for their antibacterial activity. Among the tested carboxylic acids, I [R = H ; X = H] was most active against representative Gram-pos. and Gram-neg. bacterial strains and these compounds were also active against Methicillin-resistant Staphylococcus aureus (MRSA) with very low toxicity to the normal cells. Virtual screening using ligand-protein docking modeling predicted that the compounds I [R = H] were potential inhibitors of the topoisomerase IV enzyme and that hydrophobic interactions and hydrogen bonds were the major mol. interactions between these compounds and the residues of the active site of topoisomerase IV.
Archiv der Pharmazie (Weinheim, Germany) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics