Adam, Jean-Michel published the artcileDevelopment of a Scalable Synthesis of (S)-3-Fluoromethyl-γ-butyrolactone, Building Block for Carmegliptin’s Lactam Moiety, Quality Control of 115314-17-5, the publication is Organic Process Research & Development (2011), 15(3), 515-526, database is CAplus.
Several new routes are reported for the synthesis of (S)-3-fluoromethyl-γ-butyrolactone. An asym. hydrogenation-based synthesis was chosen as the enabling route to produce the lactone on a 10-kg scale. A superior stereoselective route starting from (S)-tert-Bu glycidyl ether which afforded the desired lactone in three steps with ∼50% overall yield was finally selected for further development and production
Organic Process Research & Development published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Quality Control of 115314-17-5.
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https://en.wikipedia.org/wiki/Ester,
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