Synthesis of Pentafluorinated β-Hydroxy Ketones was written by Zhang, Peng;Wolf, Christian. And the article was included in Journal of Organic Chemistry in 2012.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:
The LHMDS-promoted in situ generation of difluoroenolates from readily available 1-aryl and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione hydrates has been used to produce a series of pentafluorinated β-hydroxy ketones in up to 95% yield. The reaction proceeds under mild conditions, tolerates a wide range of functional groups, and is complete within 10 min. Reduction toward the corresponding 1,3-diol with DIBAL gives quant. amounts and favors the formation of the syn-isomer. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).
Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics