Study on synthesis of some paracetamol derivatives was written by Truong, Phuong;Huynh, Thi Hai Van;Trinh, My Hoang. And the article was included in Tap Chi Duoc Hoc in 2009.Reference of 5003-48-5 The following contents are mentioned in the article:
Propacetamol hydrochloride and benorilate (paracetamol derivatives) were obtained from low-cost materials, such as aspirin [i.e., 2-(acetyloxy)benzoic acid], paracetamol, SOCl2, chloroacetic acid and diethylamine. The process was simple and appropriate for Vietnamese manufacturing conditions. The purity of propacetamol hydrochloride and benorilate was confirmed by thin layer chromatog. Propacetamol hydrochloride was assayed by non-aqueous titration method while benorilate was determined by application of a nitrogen method. Both products conformed to standards by BP 2005. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics