Synthesis and antiproliferative evaluation of some novel quinazolin-4(3H)-one derivatives was written by Salem, Marwa Sayed;Al-Mabrook, Selima Ali Mohamed;El-Hashash, Maher Abd El-Aziz Mahmoud. And the article was included in Journal of Heterocyclic Chemistry in 2020.Related Products of 604-69-3 The following contents are mentioned in the article:
A series of novel quinazolinone derivatives was designed and synthesized. The antiproliferative activities were evaluated in vitro using MTT assay against hepatocellular carcinoma (HepG-2) and mammary gland breast cancer (MCF-7). The preliminary bioassay results demonstrated that tested compounds exhibited antiproliferation in various degrees. Triazole moiety enhanced the activity against the two cell lines when incorporating with quinazolinone moiety in a single mol. framework. Acetohydrazide-quinazolinone derivative showed strong activity against the two cancer cells comparable to that of doxorubicin. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Related Products of 604-69-3).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 604-69-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics