Dihydroretinoic acids and their derivatives. Synthesis and biological activity was written by Pawson, Beverly A.;Cheung, H. C.;Han, Ru-Jen L.;Trown, Patrick W.;Buck, Margaret;Hansen, Roseanne;Bollag, W.;Ineichen, U.;Pleil, H.. And the article was included in Journal of Medicinal Chemistry in 1977.Formula: C12H18O3 The following contents are mentioned in the article:
The preparation of the saturated ring analog [19907-33-6] and 12 side-chain dihydro derivatives of retinoic acid are described as well as the activities of the compounds in a chem.-induced mouse skin papilloma test and 2 in vitro vitamin A deficient assays. Dihydro derivatives I [51077-50-0], II [57399-31-2], and III [62924-38-3] retained activity in the papilloma test, but were less potent than the side-chain tetraene parents. I retained significantly more activity than the other dihydro derivatives in the in vitro assays. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5Formula: C12H18O3).
(2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C12H18O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics