Expeditious Scalable Catalyst-Free One-Pot Synthesis of 4-Alkoxy-5-amino-3-methylthiophene-2-carbonitriles via Sequential Reactions of Lithiated Alkoxyallenes with Isothiocyanates and 2-Bromoacetonitrile was written by Nedolya, Nina A.;Tarasova, Olga A.;Albanov, Alexander I.;Trofimov, Boris A.. And the article was included in Synthesis in 2018.Related Products of 2253-73-8 The following contents are mentioned in the article:
A synthetically simple and convenient approach to tetrasubstituted thiophenes with rare combination of the alkoxy, amino and cyano groups was developed. The assembly of polyfunctionalized thiophene ring was implemented in one preparative step by sequential addition of isothiocyanate and 2-bromoacetonitrile to the lithiated (with n-BuLi) alkoxyallene. The reaction proceeded through in-situ formation and intramol. cyclization of cyanomethyl 2-alkoxy-N-buta-2,3-dienimidothioate (1-aza-1,3,4-triene). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Related Products of 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics