Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation was written by Li, Hui;Hu, Yan;Wang, Xueyan;He, Guangwei;Xu, Yungen;Zhu, Qihua. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Electric Literature of C7H6N2O5 The following contents are mentioned in the article:
8,9-Dihydro-2,4,7,9a-tetraazabenzo[cd]azulen-6(7H)-ones were designed and synthesized as a new class of PARP-1/2 inhibitors. The compounds displayed a variable pattern of PARP-1/2 enzymes inhibition profile that, in part, paralleled the antiproliferative activity in cell lines. Among them, compound 9e exhibited not only the significant IC50 value of 28 nM in the PARP-1 and 7.7 nM in PARP-2 enzyme assay, but also a profound synergic efficacy combined with temozolomide with PF50 values of 2.6, 2.5, and 6.5 against MDA-MB-468, SW-620 and A549 and cell line, resp. This study involved multiple reactions and reactants, such as Methyl 4-hydroxy-5-nitronicotinate (cas: 1214387-19-5Electric Literature of C7H6N2O5).
Methyl 4-hydroxy-5-nitronicotinate (cas: 1214387-19-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C7H6N2O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics