Zwitterionic sulfobetaine inhibitors of squalene synthase was written by Spencer, Thomas A.;Onofrey, Thomas J.;Cann, Reginald O.;Russel, Jonathon S.;Lee, Laura E.;Blanchard, Daniel E.;Castro, Alfredo;Gu, Peide;Jiang, Guojian;Shechter, Ishaiahu. And the article was included in Journal of Organic Chemistry in 1999.COA of Formula: C12H18O3 The following contents are mentioned in the article:
A number of sulfobetaines were synthesized and evaluated as inhibitors of squalene synthase (SS) on the basis of the idea that their zwitterionic structure would have properties conducive both to binding in the active site and to passage through cell membranes. When the simple sulfobetaine moiety is incorporated into compounds containing hydrophobic portions like those in farnesyl diphosphate or presqualene diphosphate, inhibition of SS in a rat liver microsomal assay was indeed observed A wide variety of structural modifications was investigated. Unfortunately, no inhibitors in the submicromolar range were discovered, and exploration of a different type of zwitterion seems necessary if this appealing approach to inhibition of SS is going to provide a potential antihypercholesterolemic agent. This study involved multiple reactions and reactants, such as (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5COA of Formula: C12H18O3).
(2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C12H18O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics