Seki, Toshimi published the artcileStudies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665, SDS of cas: 115314-17-5, the publication is Chemical & Pharmaceutical Bulletin (1998), 46(1), 84-96, database is CAplus and MEDLINE.
Synthesis of the four optical isomers of TZC-5665, a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinones with chiral glycidyl ethers. The hypotensive and β-blocking activities of TZC-5665 and its optical isomers were examined when given i.v. into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III.
Chemical & Pharmaceutical Bulletin published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C8H10S, SDS of cas: 115314-17-5.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics