A convergent stereocontrolled synthesis of [3-14C]solanesol was written by Roe, Stephen J.;Oldfield, Mark F.;Geach, Neil;Baxter, Andrew. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2013.Electric Literature of C12H18O3 The following contents are mentioned in the article:
In this communication, we report the synthesis of â? mCi of [3-14C]solanesol (I) prepared from Et [3-14C]acetoacetate and (all-E)-octaprenyl bromide (II) in four steps, with a specific radioactivity of 19.83 mCi/mmol and with a chem./stereochem. and radiochem. purity of â?95%. Position 3 of the chain was selected for 14C labeling because of the metabolic stability of this position. Unlabeled (all-E)-octaprenol III necessary for this work was prepared via a convergent iterative ‘allyl-allyl’ coupling approach of precursors easily derived from readily available inexpensive starting materials.1 Copyright © 2013 John Wiley & Sons, Ltd. This study involved multiple reactions and reactants, such as (2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5Electric Literature of C12H18O3).
(2E,6E)-3,7-Dimethyl-8-oxoocta-2,6-dien-1-yl acetate (cas: 37905-02-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C12H18O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics