Optimization of preparation of lycopene nanostructured lipid carrier by genetic algorithm combined with response surface method was written by Ma, Yong-qiang;Tan, Zhen-hong;Li, Chen-chen;Xiu, Wei-ye;Jing, Hong-shu. And the article was included in Baozhuang Gongcheng in 2022.Computed Properties of C21H44O5 The following contents are mentioned in the article:
In order to improve the bioavailability and stability of fat soluble lycopene, lycopene nanostructured lipid carriers were prepared by melting high-speed shear method. Taking the entrapment efficiency and average particle size as the main evaluation indexes, the single factor test was carried out, and the preparation process was optimized by genetic algorithm combined with Box-Behnken response surface method. The theor. entrapment efficiencies optimized by genetic algorithm and Box-Behnken response surface method are 86.2082% and 86.1695%. By validation test, the actual entrapment efficiency and average particle size were (86.267±0.44)% and (121.8±5.20) nm. The results show that the optimization of lycopene nanostructured lipid carrier model by genetic algorithm combined with Box-Behnken response surface method is reliable. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics