Lund, Birgitte W. published the artcileDesign, Synthesis, and Structure-Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2009), 52(6), 1540-1545, database is CAplus and MEDLINE.
We recently discovered the isoform selective RARβ2 ligand 4′-octyl-4-biphenylcarboxylic acid (3, AC-55649)(I). Although 3 is highly potent at RARβ2 and displays excellent selectivity, solubility issues make it unsuitable for drug development. Herein we describe the exploration of the SAR in a biphenyl and a phenylthiazole series of analogs of 3. This ultimately led to the design of 28 (II), a novel, orally available ligand with excellent isoform selectivity for the RARβ2.
Journal of Medicinal Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics