Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents was written by Lu, Huagang;Rogowskyj, John;Yu, Wenquan;Venkatesh, Anu;Khan, Noshena;Nakagawa, Shigeki;Goossens, Nicolas;Koh, Anna P.;Higashi, Takaaki;Gunasekaran, Ganesh;Schwarz, Myron E.;Hiotis, Spiros P.;Xu, Xiaodong;Kinney, William;Hoshida, Yujin;Block, Timothy;Cuconati, Andrea;Du, Yanming. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Computed Properties of C7H14O3 The following contents are mentioned in the article:
Based on our previous identification of a disubstituted aminothiazole termed HBF-0079 with promising selective toxicity for HCC-derived cell lines vs. non-HCC liver lines, a series of tri-substituted aminothiazole derivatives were prepared and evaluated. This work resulted in the discovery of iso-Pr 4-(pyrazin-2-yl)-2-(pyrimidin-2-ylamino)thiazole-5-carboxylate (I), which displayed EC50 value of 0.11 μM and more than 450 times of selectivity, and its Me carbonate prodrug with improved solubility in organic solvents. Furthermore, I was shown to reduce the proliferation of several liver cancer cells derived directly from patients. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Computed Properties of C7H14O3).
Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C7H14O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics