Gautam, Anurag Kumar published the artcilePreclinical evaluation of dimethyl itaconate against hepatocellular carcinoma via activation of the e/iNOS-mediated NF-κB-dependent apoptotic pathway, COA of Formula: C7H10O4, the publication is Frontiers in Pharmacology (2021), 823285, database is CAplus and MEDLINE.
Hepatocellular carcinoma (HCC) is one of the most common tumors affecting a large population worldwide, with the fifth and seventh greatest mortality rates among men and women, resp., and the third prime cause of mortality among cancer victims. Di-Me itaconate (DI) has been reported to be efficacious in colorectal cancer by decreasing IL-1β release from intestinal epithelial cells. In this study, diethylnitrosamine (DEN)-induced HCC in male albino Wistar rats was treated with DI as an anticancer drug. The function and mol. mechanism of DI against HCC in vivo were assessed using histopathol., ELISA (ELISA), and Western blot studies. Metabolomics using 1H-NMR was used to investigate metabolic profiles. As per mol. insights, DI has the ability to trigger mitochondrial apoptosis through iNOS- and eNOS-induced activation of the NF-κB/Bcl-2 family of proteins, CytC, caspase-3, and caspase-9 signaling cascade. Serum metabolomics investigations using 1H-NMR revealed that aberrant metabolites in DEN-induced HCC rats were restored to normal following DI therapy. Furthermore, our data revealed that the DI worked as an anti-HCC agent. The anticancer activity of DI was shown to be equivalent to that of the com. chemotherapeutic drug 5-fluorouracil.
Frontiers in Pharmacology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, COA of Formula: C7H10O4.
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https://en.wikipedia.org/wiki/Ester,
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